Autotaxin: inhibiting a greasy pocket Medicinal significance of autotaxin

  • Published 2011 in


Autotaxin (ATX) is a secreted glycoprotein that has been implicated in various physiological and pathophysiological processes, including vascular and neural development, lymphocyte trafficking, fibrosis and tumour progression. ATX functions as lysophopholipase D (lysoPLD), hydrolysing lysophosphatidylcholine (LPC) into the signalling lipid lysophosphatidic acid (LPA). LPA stimulates cell migration, proliferation and survival in many cell types by binding to specific G protein-coupled receptors (GPCRs). Given its emerging role in disease, ATX is actively pursued as a drug target in both academia and industry.


    0 Figures and Tables

      Download Full PDF Version (Non-Commercial Use)